本案例為一位30歲女性從馬來西亞回來之後開始高燒、骨頭痛及全身紅腫，所以進入本院做進一步檢查治療。當時醫師診斷為疑似登革熱的感染，給予acetaminophen等藥品作為支持性療法。

出院幾天後，病患發生更嚴重的皮膚疹，懷疑是因為合併使用lamotrigine和valproic acid而造成的皮膚過敏反應。當時隨即將lamotrigine停用並給予steroid和antihistamine治療。本文藉由此案例的報導希望提醒醫療同仁對於臨床藥事照護服務之警覺。
 

This is a case of 30-year-old female started having fever, bone pain and systemic rash after came back from Malaysia. Due to the patient’s sign and symptoms and dengue epidemics in Malaysia, she was diagnosed as having dengue and given acetaminophen for supportive treatment.

After few days of discharge, she had developed even more severe skin rash over whole body than the first time of admission. The severe skin rash may occur with the use of both lamotrigine and valproic acid. Lamotrigine was then discontinued and she was given steroid and antihistamine for symptom relief. Based on our case report, clinicians should be aware of the possible severe skin rash when coadministration of lamotrigine with valproic acid.