研究方法：我們設計了5 種臨床常見esomeprazole 錠通過鼻胃管投藥條件，包含(鼻胃管材料、稀釋液的容量、鼻胃管沖洗次數、連續管灌時間和合併營養配方灌食等影響因素)，經收集灌食液、過濾，並且透過高壓液相層析儀分析樣品，以了解esomeprazole 經管灌投藥是否會造成有效劑量損失。

研究結果：Esomeprazole 藥錠以25 或50 mL 的蒸餾水崩散成懸浮液，並且透過注射器注入16號鼻胃管，再另外以25 或50 mL 蒸餾水沖洗管壁，結果顯示在第一次的沖洗後，藥物的通過量有明顯的差異(p < 0.05)。Esomeprazole 管灌通過量累積百分比顯著受到鼻胃管材質、稀釋液容量、管壁沖洗容量和營養灌食配方影響，但在藥品管灌後的沖洗頻率、超過七天以上的連續管灌結果沒有顯著差異。經不同材質之16 號鼻胃管執行Isocal 營養配方灌食後，投與esomeprazole 水溶液 (esomeprazole 錠劑40 mg 溶解於25 mL 蒸餾水)，收集第一天管灌後，直接通過16 號鼻胃管之殘餘含藥溶液之體積，經HPLC 分析出殘餘藥量百分比於使用polyvinyl chloride 管為38.3%，相對polyurethane 管為43.0%。

結論：Esomeprazole 錠劑的管灌劑量，在通過鼻胃管時易受到餵食管材質、管灌水量及營養配方之管理措施影響，將會影響藥療品質和醫療保健的成本效益。我們建議需管灌時，esomeprazole
錠劑以50 mL 蒸餾水崩散成懸浮液，並使用50 mL 的蒸餾水沖洗管壁，可增加管灌通過率，減少esomeprazole 劑量損失。

Purpose:To determine esomeprazole delivery efficiency during transit through the nasogastric tubes.
Methods:We assessed the influence of 5 variables (the type of 16-French nasogastric tube materials, dilution solvent volume, administration pattern, treatment duration time, and delivery nutrition factor) on esomeprazole tablets delivered via nasogastric tube to determine whether esomeprazole was lost during transit through the tube. Samples were filtered and analyzed by HPLC.
Results:Esomeprazole pellets were suspended in 25 or 50 mL water and administered through a syringe into a 16-French nasogastric tube, and when rinsed with an additional 25 or 50 mL of distilled water, a significant difference (p < 0.05) in results was obtained at the first washing. The cumulated percentage of esomeprazole was significantly affected by tube material, dilution solvent volume, water rinsing volume,and nutrition administration, but no significant difference existed between the frequency of water rinsing or the tube incubation duration after 7 days. When esomeprazole was administered after Isocal nutrition,the percentage of esomeprazole collected was directly related to the type of 16- French nasogastric tube (polyvinyl chloride, 38.3% vs. polyurethane, 43.0%), as analyzed in 25 mL water at day 1.
Conclusion: The efficiency of esomeprazole tablets when delivered via nasogastric tubes is affected by the administration process, which may affect the quality of pharmacotherapy and the cost-effectiveness of healthcare. We suggested that esomeprazole tablets required the 50 mL of distilled water for the first injection to avoid loss of esomeprazole.