Objective: The aim of this study was to develop an ICD coding database for drug-disease contraindications. This drug-disease contraindication database was to be coded in a way that allowed physicians to check/screen patient medical records while prescribing drugs. This drug-disease contraindications knowledge base was then tested by analyzing the prevalence of drug-disease contraindications among one million outpatients. 
Methods: This study involved a two-staged survey which was conducted by both pharmacists and disease classification specialists. The drug-disease contraindications knowledge base was tested by analyzing the prevalence of drug-disease contraindications among one million outpatients. Main outcome measures were the frequency of contraindications per drug, drug-disease contraindications by pharmacological classification of drug, and drug-acute narrow angle glaucoma contraindications. 
Results: Twenty-nine percent of drugs prescribed were found to have one drug-disease contraindication and 19% had two drug-disease contraindications. Twenty-point eight percent of drugs coded with contraindications were central nervous system agents, 18.4% of drugs coded with contraindications were cardiovascular drugs. The frequency of drug-acute narrow angle glaucoma contraindications among 275 patients with acute narrow angle glaucoma from one million outpatients was 4 (1.5%) for the drug diazepam. 
Conclusion: In order to improve medication safety, it is important to develop a clinical decision support system with an effective and clinically relevant knowledge base of drug–disease contraindications.
 

目的：研究的目的為建立一個藥品禁忌症ICD編碼資料庫，能在醫師開方時進行已開方藥品與病人診斷ICD編碼的比對。此外也利用門診病人的就醫及用藥資料，來測試此藥品禁忌症ICD編碼資料庫。
方法：先由藥師根據MICROMEDEX® and AHFS，建立醫院處方集中的藥品禁忌症資料庫，再交由疾病分類員進行禁忌症ICD編碼。主要的研究結果為每個藥品的禁忌症個數分佈頻率，具藥品與疾病禁忌的藥品藥理分類個數分佈頻率，以及急性狹角性青光眼病人禁忌症用藥的盛行率。
結果：29%藥品具有1個藥品與疾病禁忌，19%藥品具有2個藥品與疾病禁忌。20.8%具藥品與疾病禁忌的藥為中樞神經用藥，18.4%具藥品與疾病禁忌的藥為心血管用藥。在275個急性狹角性青光眼病人中，有4 (1.5%)個病人的處方藥中有diazepam，為藥品與疾病禁忌。
結論：為了增進病人用藥安全，於臨床決策支援系統建立一個有效以及臨床相關的藥品禁忌症ICD編碼知識庫是很重要的。