Clopidogrel  在臨床上經常被用於腦血管、心血管或周邊動脈血管阻塞性疾病之預防與 治療。文獻指出  Clopidogrel  的皮膚不良反應發生率約有  3-4%，但目前尚未有因服用 Clopidogrel 引起伴隨嗜酸性白血球增多全身過敏反應的文獻報告。（DRESS-Drug Rash with Eosinophilia and Systemic Symptoms）。
本案例起初懷疑是因服用 zolpidem 所造成的藥物不良反應，但經回顧個案所有的病史 及藥物史較傾向於是因使用 Clopidogrel 所造成的伴隨嗜酸性白血球增多全身過敏反應且伴 隨感染併發症致死。希望藉由此個案報告，能讓更多病患、照護者及臨床醫護人員熟悉此 一病症的歷程，能及早發現並採取相關醫療措施以維護病人用藥安全。

Clopidogrel is an antiplatelet agent and uses in the treatment of cardiovascular disease, peripheral arterial  disease  and  cerebrovascular  disease.  Dermatologic  adverse  reaction  have  been  reported  with clopidogrel use in 3-4%. The incidence of clopidogrel-induced drug rash with eosinophilia and systemic symptoms (DRESS) has not been reported in the literature so far.
The  unusual  presentation  of  this  rare  case-clopidogrel  induced  drug  rash  with  eosinophilia  and systemic symptoms is discussed. Zolpidem was highly suspected as offending drug initially. But, after we established a list of drugs used within the 8 weeks preceding the onset of symptoms, clopidogrel was the  culprit  and  zolpidem  was  ruled  out.  We  hope  patient,  care  giver  and  medical  staff  must  be  well informed about the causal drug for preventing adverse reaction occurred.