We reported 2 cases of delayed hypersensitivity reactions (HSrs) to oxaliplatin. Both patients had colon cancer and received adjuvant combination chemotherapy with the FOLFOX (Folinic acid/Fluorouracil/Oxaliplatin) regimen. Each patient experienced 3 episodes (total 6 episodes) of delayed HSrs to oxaliplatin.On average, HSrs developed 8.5 hours (ranging from 6 to 12 hours) after complete infusion of oxaliplatin.Fever was the most common presentation of this delayed-type hypersensitivity in our patients. In all febrile occasions, fever subsided shortly after administering an antihistamine. The association of HSrs and oxaliplatin was high according to evaluation by the Naranjo score. In our experience, such delayed HSrs may be prevented by antihistamine prophylaxis and prolonged infusion time (up to 4 hours) of oxaliplatin.