糖尿病為國人十大死因中的第四位，加上糖尿病的許多合併症，使得糖尿病患 醫療花費是經濟上的極大負擔。藥師對於抗糖尿病藥物使用現況及相關影響因子若 能夠熟悉將有助於整體照護。本研究採回溯性分析東部某醫學中心門診第 2 型糖尿 病患之抗糖尿病用藥種類、型態及影響因素。結果顯示每位病患使用抗糖尿病藥物 種類數平均為 2.01±0.90 種。胰島素(insulin)使用比率為 19.0%，口服抗糖尿病藥物 中以雙胍類(biguanids)使用率最高 62.7%，較新的口服抗糖尿病藥物中以唑烷二酮 類(thiazolidinediones)增加最多，使用率達 34.4%。合併藥物治療成為主要趨勢，佔66.8%，目前仍以雙胍類加上磺醯尿素類(sulfonylureas)為最常見的組合。影響用藥 種類之因素為年齡、專科別及加入照護網與否。
 

The diabetes mellitus (DM) is the fourth leading causes of death in Taiwan. The disease is associated with a lot of macrovascular and microvascular complications that caused a grate deal of financial burden to patients to treat those complications. If pharmacists can be more familiar with prescribing patterns and influence factors for preseribing, they could help provide better care for those patients. This retrospective study included 3473 type 2 diabetic outpatient between Jul 2005 and Jun 2006 in a medical center. The average number of antidiabetic agents used in each patient is 2.01±0.9. The overall prescribing rate of insulin is 19.0%. The highest prescribing rate of oral antidiabetic drug (OAD) is biguanides (62.7%). The newer OAD, thiazolidinediones, is used more often than α-glucosidase inhibitors and meglitinide. Biguanides plus sulfonylureas is the most commonly prescribed combination therapy. The influence factors for prescribing pattern included patient’s age, physician specialty and whether patient joined the Shared-Care System or not.