休克引起之低血壓為加護病房常見疾病，可使用輸液或升壓劑來改善病人血壓，然而，當病人情況穩定，但因血壓因素無法停止使用升壓劑時，可能延長病人於加護病房的住院時間，進而引發更多併發症。Midodrine 為 α1 agonist，藉由血管收縮造成血壓增加，臨床上常用於姿態性低血壓或透析低血壓的治療。近年來，有許多證據顯示，midodrine 可應用於加護病房的病人，經由升壓的作用來減少病人使用針劑升壓劑的時間，以及減少加護病房住院天數，且無嚴重副作用，但亦有部分文獻指出 midodrine 並無法減少針劑升壓劑使用時間，而目前僅有的隨機臨床試驗顯示midodrine 無法使病人提早停用針劑升壓劑，因研究結果不一致，期望未來能有更多隨機臨床試驗，來確立 midodrine 在加護病房中的治療角色。

Hypotension caused by shock is a common clinical problem among patients in the intensive care unit (ICU). Intravenous fluids or vasopressors are often used to improve blood pressure. However, when the patients become stable but have to use vasopressors due to hypotension, the length of stay may be prolonged, leading to more complications. Midodrine as an α1 agonist increasing blood pressure through asoconstriction is often used for patients with orthostatic hypotension or dialysis hypotension. On the one hand, a lot of evidence has shown that midodrine can be applied to ICU patients to shorten the time of vasopressor use, the length of stay, and no severe side effects. On the other hand, some literature has indicated that the use of midodrine cannot shorten the time of vasopressor use and only one randomized control trial has presented similar results. Due to the inconsistency of evidence, more randomized clinical trials on the therapeutic role of midodrine in the ICU are needed in the future.