Carbamazepine是用來治療癲癇的藥物,包括generalized tonic-clonic, partial, and mixed partial and generalized seizure disorders。Carbamazepine常造成神經方面的副作用、Stevens-Johnson syndrome及血液方面的不良反應,而肝臟方面的不良反應則較少見,但卻可能致死。本文報告ㄧ位49歲的女性患者,因左手臂疼痛,醫師處方carbamazepine服用後造成急性肝炎的案列。患者於停用carbamazepine後肝臟酵素(GOT, GPT)於五天內降至50%以上,停藥20天後,血小板由原先之72000/ul逐漸回升至119000/ul,病患排除為A、B、C型肝炎造成的急性肝炎,懷疑為carbamazepine造成的急性肝炎。
Carbamazepine is used to manage generalized tonic-clonic, partial, and mixed partial and generalized seizure disorders. It is frequently associated with neurologic adverse drug reaction, Stevens-Johnson syndrome, and hematologic side effects. Hepatic adverse effects are less common but can cause death. A 49-year-old female receiving carbamazepine for peripheral neuropathy and development acute hepatitis. With discontinuation of the drug, her liver transaminase decreased more than 50% within 5 days, suspected carbamazepine induced acute hepatitis.