Objective: This study was conducted through a home pharmaceutical care at a medical center, by the hospital pharmacist counseling high users of medical resources (HUMR). Patients were assessed on the improved of medical attitudes, medication cognition and behavior; the number of reductions of visits. Methods: Include 100 HUMR outpatient clinics of a medical center in eastern Taiwan, The study design was a cross-sectional, research tools use structured questionnaires, a total two times home visits and questionnaires, and give appropriate health education. The results were as follows: the average number of visits, medical attitude, medication cognition and behavior. Statistical analysis was performed descriptively and independent sample t-test with difference analysis of chi - square test. Results: Before visit by pharmacists, the average number of outpatient visits in the previous year was 66 times year, visiting doctors up to 3 or more 69.8%, from the health care personnel to obtain medical knowledge 67.7%. After visit, the average number of visits reduced to 42 times, receiving more than 3 doctors reduce to 63.4%, from the health care personnel to obtain medical knowledge increased to 77.1%. There were significant differences in medical attitude and medication cognition (p < 0.05), but the medication behavior have not significant difference. Conclusions: Hospital pharmacists can use medication data to understand the HUMR outpatient clinics inappropriate medical, conduct home visits and counseling. In addition to reducing the number of patient visits, but also improve patient safety medication.