L-Asparaginase（ASP）為治療兒童急性淋巴母細胞白血病（acute lymphoblastic leukemia；ALL）和T-Cell malignant lymphoma的重要治療用藥，它的有效性及重要性已被確立，但是ASP有些不良反應雖然罕見但卻足以致命。本文提出此案例為2歲女孩，以ASP與vincristine, epirubicin, steroid治療ALL。在完成緩解誘導期後，引起急性壞死性胰臟炎而入院治療，治療包括手術、放置鼻胃管抽吸、禁食給予TPN、矯正電解質異常、控制血糖、治療感染、並給予octreotide等。在情形穩定後轉回台北馬偕繼續化學治療，目前此患者已回到本院追蹤治療，但仍需以胰島素控制血糖。

L-Asparaginase (ASP) is a useful antileukemic agent for childhood acute lymphoblastic leukemia (ALL) and T-Cell malignant lymphoma. Its effectiveness and importance have been established, but there are some adverse reactions, which are rare but severe enough to cause fatality. We reported a 2-year-old girl who was the victim of ALL was treated with ASP combination with vincristine, epirubicin, and steroid. She was admission again, which induced acute necrotizing pancreatitis after complete remission therapy. During the hospitalization, she was treated with aggressive support therapy including surgery, bowel rest, nasogastric suctioning, parenteral nutrition, corrected electrolytic imbalance, control blood sugar, control infection, and intravenous octreotide. When condition stabilized, she was transferred to Taipei MMH for continuing chemotherapy. Now, she is follow up on continuing blood sugar control with insulin.