社團法人臺灣臨床藥學會

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【原著】醫院藥師介入腦中風門診病人高血壓改善之研究評估
Study of Improvements in Hypertension of Stroke Outpatients by Hospital Pharmacist Intervention
腦中風、高血壓、藥師介入、stroke, hypertension, pharmacist intervention
邱春吉Chun-Chi Chiu*1 、張谷州Ku-Chou Chang2 、簡淑娟Shu-Chuan Chien3 、李炳鈺Ping-Yu Lee1 、吳信昇Shihn-Sheng Wu4
1高雄長庚紀念醫院 藥劑科 、2高雄長庚紀念醫院 神經內科 、3高雄長庚紀念醫院 護理部 、4高雄醫學大學 藥學院
前言:腦中風在全世界是造成死亡率與罹病率增加的最主要因素之一,而在國
內根據行政院衛生署的統計它是第二常見的死亡原因。高血壓是引起腦中風之重要 且確立的可治療危險因子與預測因子。雖然許多研究顯示治療高血壓可減少腦中風 病人的罹病率與死亡率,而在治療上也有詳盡的建議準則當參考,但目前仍有許多 腦中風門診病人的血壓未能有效控制,適當的藥事照護對於血壓之控制還有明顯的 改善空間。
目的:測定藥師介入神經科門診腦中風病患藥事照護,評估改善腦中風相關危 險因子高血壓的成效。
方法:本研究為一項前瞻性、等量分層隨機取樣之臨床試驗,經隨意取樣 160 位病患分配為實驗組 80 人和對照組 80 人,實驗組接受藥師積極介入之藥事照護研 究計畫,對照組則如醫院一般程序。主要指標是(1)兩組內與兩組間收縮壓、舒 張壓,相較於基準點之變化差異;(2)高血壓相較於基準點之達控制目標比例,以 及評估研究後改善的比例。
結果:實驗組在收縮壓和舒張壓有明顯意義的改善;對照組則無改善。實驗組 符合高血壓控制情形的人數比例改善了 37  %(P =  0.00);對照組符合高血壓控制 情形的人數比例並未有明顯意義改善且明顯變差(P = 0.013)。
結論:我們的研究顯示,醫院藥師提供藥事照護,對於腦中風門診病人血壓之 改善有顯著的統計意義。因此,藥師介入初級門診醫療照護體系,對腦中風門診病人血壓之改善有明顯助益,對病患健康照護之結果有正面的影響。

Background: Stroke is one of the leading factors of morbidity and mortality worldwide. It represents the second most common cause of mortality in Taiwan. Hypertension is an important and established modifiable risk factor and predictor for stroke. Although many studies had demonstrated treatment of hypertension can reduce morbidity and mortality of stroke patients. But still had many stroke patients inadequate management of hypertension despite explicit management recommendations. There are marked rooms for improvement in the management of hypertension.
Objective: To determine the efficacy of pharmacist intervention in the management of hypertension in the neurologic stroke outpatient.
Method: This was a prospective and equal allocation stratified random sampling clinical trial. One-hundred sixty patients were randomly assigned to experimental (n=80) or control (n=80) group. The experimental group received pharmacist intervention while the control group did as routine. Primary endpoints were (1) the differences of within groups and between groups of systolic blood pressure, diastolic blood pressure levels from baseline to the end of study. (2) the proportion of adequate management or assessed improvement of hypertension from baseline to the end of study.
Results: In the experimental group had significant improvement in systolic blood pressure and diastolic blood pressure. In the control group did not improved in blood pressure. Hypertension adequate management improved 37 % (P = 0.00) in the experimental group. There was no significant improvement in hypertension adequate management in the control group.
Conclusion: Our study was indicated that pharmacist-managed hypertension program integrated into a primary care medical clinic can effectively improve blood pressure control in stroke outpatients and positive impact on patient health care outcomes.
 
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