The novel approved agent idarucizumab, a monoclonal antibody fragment, binds dabigatran immediately to reverse its anticoagulative effects. We reported the experience of intravenous thrombolysis therapy in an acute ischemic stroke after dabigatran reversal with idarucizumab. The treatment was feasible and no hemorrhage or complications were observed. This case represents a new therapeutic paradigm for acute ischemic stroke.