術後病人發生噁心和嘔吐 (Post-operative Nausea and Vomiting；PONV) 的危險因子除了病人的年齡、性別、體重和病史等因素外，麻醉藥物、手術種類與術後施打之鴉片類止痛劑等藥物皆有相關。本研究回溯性收集2006年在本院手術病人3384人術後使用meperidine止痛劑並引發噁心嘔吐的案例，共計96人(97例)，每人meperidine總投予的劑量最少15mg，最多100mg，女性發生比例為6.6%，男性發生比例為2.8%。11歲至14歲發生比例10.7%(3/28) 高於其他年齡層。分析總投予劑量引發噁心嘔吐所需的時間和嚴重的程度，結果顯示不論是施打多少劑量，發生噁心和嘔吐的時間有44.3%在5分鐘內(含)。文獻報告meperidine的劑量和噁心嘔吐程度可能有關聯，本研究的結果則沒有顯著的差異（p=0.426），不過這可能與收集納入的案例數仍不足有關。

Beside age, gender and body weight, the risk factors of patients suffered from postoperative nausea and vomiting （PONV ） may include previous history of motion sickness and type of medication and surgical procedure. We reviewed 3384 medical records of patients who received IV meperidine in recovery room of Cathay General Hospital, Sijhih Branch in 2006 and found 97 cases developed PONV. The incidence rate of male and female is 2.8% and 6.6%. Age 11-14 has the highest incidence rate(10.7%). The meperidine dosage given range from 15mg to 100mg. We analyzed the occurring time and the severity of PONV. Our study found that 44.3% of the occurring time of meperidine-induced nausea and vomiting are within 5mins. In our study, the severity of symptom was not related to meperidine dosage. This might be due to insufficient case number collected.