儘管正確的發生率多少仍未知，藥物造成之肌肉病變的確是最常見導致肌肉疾病的原因。肌肉病變通常是一種非致死性且包含有骨骼肌肉無力、觸痛及疼痛伴隨有可能的血清中肌酸磷酸激酶上升症狀的肌肉疾病。肌肉病變的類型很多，包括與遺傳、發炎反應或與內分泌功能障礙有關的，同樣地，許多藥物也已經被報導具有肌肉毒性而且這樣的藥物不良反應現今較常見於規律的使用降血脂藥物後，尤其是HMG-CoA還原酶抑制劑(亦稱statins) 或苯氧酸衍化物這兩類的降血脂藥。

Fenofibrate為新一代的苯氧酸衍化物，臨床使用fenofibrate做為單一治療下常見的不良反應有噁心、便秘、脹氣、消化不良及胺基轉移酵素濃度的升高等；相較之下，此藥與肌肉相關的不良反應則是較罕見但仍值得注意的。此案例報告是一位在每日服用200毫克fenofibrate十天後，發生肌肉病變伴隨有肌肉疼痛及顯著血清中肌酸磷酸激酶上升症狀的病患。幸運的是，在停用fenofibrate後病患的症狀逐漸獲得改善。

Drug-induced myopathy is the most common causes of muscle disease, although the precise incidence is unknown. Myopathy is usually a non-fatal muscle disease involving skeletal muscle weakness, tenderness and pain with the possible plasma creatinine phosphokinase elevation. There are many different types of myopathies, some of which are inherited, some inflammatory, and some caused by endocrine problems. Also, numerous drugs have been reported to possess myotoxic effect and these adverse drug reactions are seen more regularly after the introduction of modern lipid-lowering drugs, particularly HMG-CoA reductase inhibitor (statins) or fibric acid derivatives. 
Fenofibrate is an advanced-generation fibric acid derivatives. Under the clinical use of fenofibrate as monotherapy, the most common adverse reactions are nausea, constipation, flatulence, dyspepsia, and elevated transaminase levels, etc. In contrast, the muscle-related side effects reported with fenofibrate are quite rare, but still needed to pay attention to. Here, we present a case of myopathy accompany with muscle pain and characteristic serum creatinine phosphokinase elevation following administration of 200 mg of fenofibrate daily for 10 days. Fortunately, patient gradually improved after stopping the drug.