前言：糖尿病人口逐年增長，疾病照護必需配合飲食控制、規律運動和藥物治療。發展糖尿病自我管理衛教模式並建立良好支持系統，有助於病人學習自我照護，預防慢性合併症發生，降低急症風險，減少醫療資源耗用。
目的：瞭解藥師介入對糖尿病人疾病知識的影響，並評估接受藥事照護後疾病代謝指標改善程度。
方法：這是一項前瞻性單盲隨機對照研究，共評估200 例第2 型糖尿病門診病人。使用健康識能評估工具結合疾病生理生化數據分析介入成效。病人被隨機分派為兩組，每組100 例。用藥衛教組透過設計的漫畫圖文教育模組接受兩階段介入，包括對疾病和服藥的瞭解及病人自我照護管理。常規衛教組僅接受常規診療服務，不介入。兩組病人皆在6 個月後接受健康識能、疾病知識、照護行為配合程度和生化檢查結果改變量評估，並應用此照護模式總結介入有效性。
結果：6 個月後，用藥衛教組相較於常規衛教組，在糖尿病健康識能改變率 (14% vs. 5%, Δp < 0.001)，疾病知識改變率 (14% vs. 1%, Δp < 0.001) 均顯著提升，進而增加健康飲食行為配合度 (Δp < 0.05)。而平均糖化血色素改變量 (-0.31% vs. 0.01%,Δp = 0.061)，平均空腹血糖改變量 (-21.43 mg/dL vs. -3.68 mg/dL, Δp = 0.063)，似有降低之改變趨勢。
結論：糖尿病連續性藥事照護模式有助於提升病人的健康識能，促進藥事照護成效。

Background: Diabetes management includes diet control, regular exercise, and medication therapy. An effective patient self-management education program was developed to increase personal self-care ability. It resulted in prevention of chronic complications, and reducing the risk of an accident, medical expenditure, and resources consumption.
Objective: This study was To explore the effect of a pharmacist intervention on patient’s disease knowledge and the level of disease improvement after pharmaceutical care.

Methods: A randomized, single-blind study was conducted with 200 outpatients with type 2 diabetes. The health literacy tool including demographics was used and lab results were assessed. Two stages of intervention education group were implemented using the designed cartoon education program including patient self-management, knowledge of the disease and administration of medication. For the conventional group, no intervention was provided. Both groups were evaluated for health literacy, disease knowledge, compliance behavior and changes in lab results six months later.

Results: Compared with the conventional group, the intervention group’s overall health literacy (14% vs. 5%, Δp < 0.001) and disease knowledge (14% vs. 1%, Δp < 0.001) were significantly improved after the pharmacist’s involvement. The analysis of patients’ compliance behaviors indicated that with respect to healthy eating, the intervention group showed a statistically significant improvement (Δp < 0.05). In addition, HbA1c (-0.31% vs. 0.01%, Δp = 0.061) and fasting blood glucose (FBG) (-21.43 mg/dL vs. -3.68 mg/dL, Δp = 0.063) value had improved for the intervention group as compared to the conventional group.
Conclusions: Pharmaceutical Continuity Care for Diabetes was effective in improving pharmaceutical care for patients with health literacy.