背景：
鬱 症會造成嚴重的社會經濟負擔，也是所有造成失能疾病的 第一名。本研究篩選門診重鬱症患者為對象進行處方型 態分析，以實際瞭解病患在臨床上使用抗憂鬱劑之情形。
方法：
利用某醫學中心之 西 醫 門 診健保申報資料庫，篩選2005年-95 年西醫門診中，診斷為重鬱症者（ 篩 選 診 斷 碼 為 296.2 及296.3），分析病患之年齡、性別、看診科別與藥物使用情形。
結果：
門診之重鬱症病患人數及藥品耗費金額有逐年增加之趨勢，處方型態分析發現，不論是處方次數 、開方率 、 耗用量或耗用金額，皆以 SSRI 類藥品為最高， 傳統之TCA 類及MAOI 類則呈逐年下降。
結論：
處方型態的分析固然印證了新一代藥物的臨床使用價值，然而 對國人而言，新一代抗憂鬱劑的藥效是否較好、更能增加服藥順 從性，仍需更多研究來佐證。如何在醫療費用日增的環境下還能確保病患的用藥品質，是刻不容緩的議題。
Background:
Depression is a growing burden on society, disabled by depression defeat both economics and quality of life. The aim of this study was to evaluate the prescribing patterns of major depression patients in a medical center.
Methods:
Data were derived from the Psychiatric department in a medical center. The study included all diagnosed major depression (ICD-9 code 296.2 and 296.3 ) outpatient who has been prescribed antidepressants from Jan 1, 2005 to Dec 31, 2006.
Results:
In our study, the prevalence of antidepressant use, prescribing rates and prescription cost of 2006 have risen when compared to that of 2005. SSRIs had a significantly higher prescribing rates and paroxetine was the most used antidepressant, the prescribing rates for TCAs and MAOI had declined year on year.
Conclusion:
Prescribing patterns evaluation help us to realize that the trend of newer antidepressant utilization has had a substantial financial impact, however, the effectiveness and compliance of newer agents for our patient still need more further studies to prove. An Evidence Based Guideline for the choice of antidepressants is most needed now.
