目標：手術部位感染會延長病人的住院天數、增加醫療費用，甚至造成病人的死亡，正確使用手術前預防性抗生素，對於降低手術部位的感染具有正面的效果，本研究目的藉由審查模式介入以改善本院手術預防性抗生素使用時機與使用期間的適當性。

方法：自2006年12月起至2009年11月止，每年至少2次審查本院手術預防性抗生素使用的適當性，六項監測指標內容，包括：1.手術劃刀前1小時內給藥；2.剖腹產在臍帶結紮切除後立即給予；3.抗生素的選用符合文獻建議；4.使用劑量與體重符合；5.手術過長需補給劑量；6.預防性抗生素於術後24小時內停用等。以評估各項指標之符合程度。

結果：本院手術預防性抗生素使用，研究期間，共審查2436件，為促進手術預防性抗生素的使用適當，持續監測及改善使用情形，各項監測指標符合率的改善如下：手術劃刀前1小時內給藥其符合率由86%改善至91%、剖腹產在臍帶結紮切除後立即給予其符合率由94%改善至100%、使用劑量與體重相符之符合率由96%改善至98%、選藥符合抗生素使用指引其各次均達100%、符合術中補給劑量者其符合率由80%改善至90%、預防性抗生素術後24小時內停用其符合率由65%改善至70%。
結論：審查手術預防性抗生素的使用適當，依不同醫療機構亦有不同的錯誤情形，將每次審查結果回饋給外科醫師執行改善並持續追蹤評值，對於手術病患降低手術感染應有實質助益。

Objective: 
Surgical wound infection prolongs hospitalization, increases medical expenses, and even leads to patient's death. Many studies have proven the efficacy of using preventive antibiotics to control surgical wound infection. This project was to improve the appropriate selection and timing of the preventive antibiotics administration rate in our institute.
Methods: 
Between December 2006 and November 2009, was examined at least twice per year by assessing six variables: (1) Antibiotics prophylaxis within 1 h before incision (2) Immediately after cord clamping in cesarean section. (3) Prophylactic antimicrobial agent that is consistent with currently published guidelines. (4) Antimicrobial dose should be adequate based on the body weight. (5) During prolonged procedures, antibiotic prophylaxis should be re-administered. (6) Duration of prophylaxis should not exceed 24 h.
Results: 
During the study period, 2436 operations were performed. We are promoting appropriate selection and timing of the preventive antibiotics administration rate. Prophylaxis administration within 1 h before incision was increased from 86% to 91%. Prophylaxis administration immediately after cord clamping was increased from 94% to100 %. Appropriate antibiotic selection was 100%. An adequate dose on the basis of body weight was increased from 96% to 98%. Re-dose for long surgery was increased from 80% to 100%. Prophylaxis duration of less than 24 h was increased from 65% to 70%. 
Conclusion: 
Audits of surgical prophylaxis are expected to detect different errors in different institutions. Feeding the information back to surgeons could improve adherence to recommended guidelines and might contribute to reduced wound infection rates.