Paclitaxel為一taxane類抗癌藥物，且為抗癌藥物中易引發過敏反應（Hypersensitivity Reaction，HSR）的藥物之一，一般來說paclitaxel所引發的過敏反應大多屬type I的HSR，且約80%的病人於投藥後10分鐘內即會發生，症狀包括低血壓、呼吸困難、蕁痲疹、紅斑性皮疹及心搏停止致死。施打此藥後產生皮膚反應，大部分認為是施打此藥外滲所引發，少部分是藥物引起的全身皮膚不良反應，且此反應屬於遲發型過敏反應（delayed hypersensitivity）。本文為一位卵巢癌患者，因施打paclitaxel八天後引起全身軀幹四肢皮膚紅疹，在確定無外滲的情況之下，經皮膚科醫師診斷確定為paclitaxel引起Erythema multiforme之罕見案例。
 

Paclitaxel is an antineoplastic agent of the taxane class, which has caused hypersensitivity reactions (HSR) in a significant proportion of patients. Generally, the manifestations of HSR from paclitaxel are typically type I, which are characterized by hypotension, dyspnea, bronchospasm, urticaria, erythematous rashes, and asystole resulting in death. The majority of the patients developed HSR within 10 minutes after the start of infusion. Most of the previously reported paclitaxel-induced dermatologic reactions occurred following extravasation. There are few reports of generalized dermatologic rashes and these rashes are thought to be due to delayed hypersensitivity. We report a woman patient with ovarian carcinoma that developed generalized scattered erythematous macular eruptions over trunk and limbs 8 days after receiving her first dose of paclitaxel. The manifestation of erythema multiforme might be induced by paclitaxel without any evidence of extravasation.