此病例是敘述一位31歲男性精神分裂症的病人，因唾液分泌過多之副作用，而自行停藥，疑似在重新服用clozapine後所產生之意識喪失嚴重藥物不良反應。這位病人長期服用clozapine治療精神分裂症，因流口水過多之副作用而停藥。約1-2星期回診時，醫師建議其重新服用clozapine以更有效控制症狀，但在重新服用clozapine約半小時後，發生意識喪失並送醫院急診急救。
Clozapine為新一代抗精神病藥，療效顯著，副作用較低。但需特別注意血液方面-顆粒性白血球缺乏之副作用，但於本次所見意識喪失之副作用則較不常見。藉由本篇闡述此意識喪失副作用，以提醒從事臨床藥物治療之人員（醫師、護士、藥師）注意。
 

We report a case of a 31-year-old male with schizophrenia who lost consciousness upon reinitiating clozapine therapy. The patient, who has been treated with clozapine over a long period of time, abruptly discontinued clozapine therapy for about 1-2 weeks due to increased salivation.  After visiting the doctor, the patient was suggested to continue on clozapine therapy.  However, about a half hour after reinitiating clozapine, the patient was admitted to the hospital emergency room with a diagnosis of loss of consciousness.  Clozapine is an effective, atypical antipsychotic drug with lower side effects, but requiring close monitoring for hematological changes, such as agranulocytosis.  Loss of consciousness was rarely seen in patients who receive clozapine treatment.