Objectives: This is a retrospective, population-based study on the relationship between medication and the first suicidal behavior in schizophrenia outpatients in Taiwan.
Methods: The insurance outpatient claims data obtained from the National Health Insurance in Taiwan from 2006 to 2010. A total of 5,515 patients with diagnosis of schizophrenia were qualified.Suicide group had 35 patients with psychiatric treatment outpatient record before initial suicidal behavior occurred. Stratified samples group had 1,122 stratified samples which were selected based on the same conditions in the corresponding suicide group. The medication analysis by computer at 1:1 stratified random sampling between 2 groups to filter out 50 sets. We made an inference of some drugs which may increase or decrease incidence of suicidal behaviors by the statistically analyzed results. Results: The drugs that may decrease the incidence of suicidal behaviors were haloperidol (5 times statistically significant), risperidone (5), sulpiride (4). The drugs that may increase the suicidal incidence were flunitrazepam (7), clonazepam (3), estazolam (2), and flupentixol (1). Conclusions: Schizophrenia is a chronic mental illness which need long-term medication treatment and medical rehabilitation. This study suggests clinicians may choose positive effects of antipsychotics haloperidol, risperidone and sulpiride instead of negative impact antipsychotic flupentixol. Also recommended that when the medical staff in the use of complementary medicines treatment, they need to pay special attention to the negative impact of the sedative hypnotic drugs f lunitrazepam, estazolam and antiepileptic drug clonazepam on suicidal behaviors.