社團法人臺灣臨床藥學會

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【案例報告】Carvedilol 用於類固醇引起的酒渣鼻之案例報告
Carvedilol for the Treatment of Steroid-Induced Rosacea: Case Report
類固醇引起的酒渣鼻、carvedilol、反彈現象、Steroid Induced Rosacea, Carvedilol, Rebound Phenomenon
蘇玉惠Yu-Hui Su 、郭震羣Chen-Chun Kuo 、楊璦瑜Ai-Yu Yang*
1高雄醫學大學附設中和紀念醫院藥劑部
Carvedilol 是非選擇性β-腎上腺素受體拮抗劑。它已被證明具有抗氧化和抗發炎,能夠有助於酒渣鼻的治療。局部類固醇首次在1951 年推出後,之後無控制地使用是常見的問題。在臉部經常過度使用局部類固醇可能會產生皮膚併發症,在酒渣鼻的臨床診斷上為「類固醇引起酒渣鼻」。如果不治療,可能引起永久性的皮膚萎縮及毛細血管擴張。將根據文獻回顧,探討類固醇引起酒渣鼻的非藥物、藥物治療。再藉由兩個案例報告,評估carvedilol 使用於類固醇引起酒渣鼻的有效性、安全性,以提供臨床醫療人員治療上的另一個選擇。
 
Carvedilol is a nonselective β-adrenergic blocking agent. It has been shown to have antioxidant and anti-inflammatory actions, which may contribute to its efficacy in rosacea. Topical steroids were first introduced for use in 1951, then uncontrolled use has been a common problem. The excessive, regular use of topical steroids on the face maybe produces skin complications, clinically indistinguishable from rosacea -- steroid-induced rosacea. If left untreated, permanent skin atrophy and telangiectasia can induced. According to the literature review, we discussed the nonpharmacologic and pharmacologic interventions for steroid-induced rosacea. We evaluated the efficacy and safety of carvedilol by literature review, hope to provied clinical staff another choice for treatment.
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