A 58 years old male patient, used to drink two bottles of wine and smoke one package of cigarette everyday for 40 years. He was found that conscious disturbance at home, disorganized speech with decreased alertness and strange hand movement were noted before admission. He was treated in a local hospital initially but in vain, then he was sent to our emergency room (ER). In ER, physical examination showed confusion consciousness, neck stiffness, epigastric pain, and ventricular premature beat (VPB). Brain computerized tomography (CT) revealed left putaminal intracerebral hemorrhage (ICH) with rupture into ventricle.Through the period in the hospital, he had three medical problems including hypertension-induced ICH,alcohol withdrawal syndrome and communicating hydrocephalus. According to literature reparts, long-term consumption of alcohol may induce hypertension and secondary ICH. Putamen is the most affected area in this kind of ICH. This patient was a typical case of intracerebral hemorrhage, alcohol withdrawal syndrome and hydrocephalus in long-term drinking patients. During the hospital ization neurosurgeon accepted phaimacists suggestion to re-evaluate the use of intravenous thiamine. Patient discharged on the 20th day. In order to help patient recovery, advise patient to inhibit wine-drinking, smoking cessation and drug therapy, familial companionship and health education of pharmacist should be considered.