惡性高血鈣是多發性骨髓瘤嚴重併發症之一，患者骨質之流失及破壞為臨床上最為常見。多發性骨髓瘤除化學治療外若未加以適當輔助治療則會產生嚴重的不良結果，如惡性高血鈣、骨疼痛、有時甚至產生骨折，這無疑對患者的生活品質造成莫大的影響。此外，更造成醫療成本增加，這包括治療藥物費用增加、延長住院天數及看護費用增加等額外之醫療支出。
對於多發性骨髓瘤患者產生惡性高血鈣常常忽略其嚴重性，為了提高醫療同仁之警覺，特此提出此一病例報告。患者為一名68歲的女性，有慢性腎衰竭及血尿症之病史，此次因復發性血尿症、下背部疼痛及下肢虛弱而至本院急診就醫治療，住院診斷為多發性骨髓瘤並伴隨有惡性高血鈣及骨折，在接受抗生素、雙磷酸鹽類藥物及降血壓藥物治療後，病患臨床狀況漸見改善。唯病患於氣切後仍難於脫離呼吸器，最後在病患臨床狀況穩定下轉至呼吸照護中心繼續治療。

The most common adverse sequela of multiple myeloma is bone loss and bone destruction. Apart from giving chemotherapy, multiple myeloma should be provided with appropriate treatment, or else serious complication such as pernicious hypercalcemia of malignancy, bone pain, or even bone fracture will occur. This will interfere the patient’s quality of life. Furthermore, this causes an increase in the cost of medical treatment, including additional medical expenses, prolonged hospitalization and needed nursing care. 
Owing to the fact that most patients of multiple myeloma always overlook its seriousness, such a case report is proposed to all medical colleagues to enhance their alertness. This patient is a sixty-eight year-old woman, with a medical history of chronic renal failure and hematuria. She hospitalized due to the recurrence of hematuria, low back pain and debilitated lower limbs. She was diagnosed as multiple myeloma with serious hypercalcemia of malignancy and fracture. She has recovered after taking antibiotics, bisphosphonates and antihypertension agent. Due to respiratory dependence, patient was transferred to respiratory care ward for further treatment under stable condition.